Zanaflex is a brand name for Tizanidine. Other brand names are also available. Zanaflex may be produced in the following medical forms:
- zanaflex 4 mg white, round tablets
- zanaflex 2 mg blue capsules
- zanaflex 4 mg white and blue capsules
- zanaflex 6 mg light blue capsules with white stripe
Zanaflex blocks nerve impulses sent to a patient’s brain which causes pain. It is to reduce pain sensations by relaxing muscle tone. Zanaflex reliefs spasticity due to its short-action muscle relaxing effect.
Zanaflex produces only a temporal effect and is used to reduce excessive muscle tonus or relief pain caused by muscle spasticity. It may also be used for treating other conditions if prescribed by doctor.
Zanaflex contains tizanidine, so it should not be used by people suffering from the following deseases:
- allergy to tizanidine
- liver disease
- kidney disease
- high or low blood pressure
- history of “Long QT syndrome”.
Zanaflex also should not be used together with the antidepressant fluvoxamine (Luvox), or the antibiotic ciprofloxacin (Cipro).
If you have any of the deceases or take the medicines mentioned above you may have to undergo special tests before treatment.
While being pregnant a patient should careful about taking Zanaflex as it may do harm to an unborn baby. There hasn’t been done any research work on whether Zanaflex can pass into breast milk. A patient should consult a doctor if being pregnant or breast-feeding a baby, or planning to get pregnant.
It may take longer time for Zanaflex to clear from the body of older patients. Each patient should follow a doctor’s instructions while undergoing treatment and taking Zanaflex.
Tizanidine (Zanaflex) is an agonist at ?2-adrenergic receptor sites. It is to reduce muscular tonus by increasing motor neurons presynaptic inhibition. While doing pharmacological studies in animals no direct effect on skeletal muscle fibers or the neuromuscular junction, and no major effect on monosynaptic spinal reflexes were discovered. Tizanidine causes a great effect on polysynaptic pathways. The general effect reached by these actions is suggested to reduce permeability of spinal motor neurons.
The imidazoline chemical structure of tizanidine is quite similar to that of clonidine and other ?2-adrenergic agonists. While studying in animals a few similarities between the two compounds, clonidine and tizanidine, were revealed. But n comparison with clonidine tizanidine was discovered to have from one-tenth to one-fiftieth (1/50) of the potency of clonidine to low blood pressure. Continue reading